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Smart 4-Day Upper-Lower Split for Hypertrophy

If you’ve spent any time in the gym, you’ve likely seen different training splits. Some people train their full body every session, while others focus on just one muscle group per day. One of the most effective and popular approaches, particularly for building muscle, is the 4-day upper-lower split.

This guide provides an insightful look into how the 4-day upper-lower split works and why it’s a superior choice for hypertrophy, which is the scientific term for muscle growth. You’ll learn how to structure your routine, choose the best exercises, and manage rest to maximize your results.

How Does A 4-Day Upper-Lower Split Work?

The 4-day upper-lower split divides your training week into two upper-body days and two lower-body days. This structure allows you to train your entire body twice a week, which is considered optimal for muscle growth for most intermediate and advanced lifters (1).

On upper-body days, you focus on muscles such as the chest, back, shoulders, biceps, and triceps. On lower-body days, you target the quadriceps, hamstrings, glutes, and calves. The goal is to stimulate muscle protein synthesis (MPS), the process your body uses to repair and build muscle, more frequently without causing excessive fatigue (2).

A typical schedule looks like this:

  • Monday: Upper body
  • Tuesday: Lower body
  • Wednesday: Rest
  • Thursday: Upper body
  • Friday: Lower body
  • Saturday: Rest
  • Sunday: Rest

This setup provides a balanced stimulus across the week, with dedicated rest days to ensure your body recovers and adapts. Research has shown that trained individuals should target each major muscle group 2-3 times per week (1), which makes this split an excellent fit.

Read more: Gym Workout Plan for Women: The Ultimate Strength and Hypertrophy Guide

What Are the Benefits of A 4-Day Upper-Lower Split vs. Other Splits?

The 4-day upper-lower split offers distinct advantages over other popular training routines, such as full-body workouts, “bro splits” (one muscle group per day), or push-pull-legs (PPL) splits.

  • Optimal Training Frequency for Hypertrophy

The primary benefit of an upper-lower split is its training frequency. By hitting each muscle group twice per week, you create more frequent opportunities to stimulate muscle growth. 

This aligns perfectly with sports science principles that suggest that stimulating a muscle every 2-4 days is ideal for hypertrophy (1). In contrast, a bro split only trains each muscle once a week, which can be suboptimal for maximizing growth.

  • Better Recovery and Fatigue Management

In comparison to full-body workouts performed four times a week, the upper-lower split is easier to recover from. Training the full body can be systemically taxing, and doing it frequently can lead to burnout (3). 

The upper-lower split allows specific muscle groups to recover for at least 72 hours while you train other parts of your body. This effective fatigue management means you can maintain high intensity in your workouts throughout the week (4).

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  • Balanced Volume and Intensity

This split allows you to dedicate enough training volume to each muscle group without making individual workouts excessively long or draining.

You can perform multiple exercises for your chest, back, and legs on their respective days, ensuring you accumulate the 8-12+ sets per week recommended for hypertrophy (5). This is harder to achieve in a full-body routine without spending hours in the gym.

How Do You Structure a 4-Day Upper-Lower Split for Muscle Growth?

Structuring your split correctly is crucial for maximizing hypertrophy. Here’s a step-by-step guide to building your program.

Prioritize Compound Movements

Your workouts should be built around multi-joint, compound exercises. These movements recruit multiple muscle groups at once, which allows you to lift heavier weights and create significant mechanical tension, a primary driver of muscle growth (6).

Start each workout with 1-2 heavy compound lifts.

  • Upper Body Days: bench press, barbell rows, overhead press, pull-ups
  • Lower Body Days: squats, deadlifts, leg press, lunges

Add Isolation Exercises for Targeted Growth

After your main compound lifts, include isolation exercises to target specific muscles. These single-joint movements are excellent for adding training volume and addressing weak points (7). This follows the principle of transitioning from multi-joint to single-joint exercises within a session.

  • Upper Body: dumbbell flyes, lat pulldowns, lateral raises, bicep curls, tricep extensions
  • Lower Body: leg extensions, hamstring curls, glute bridges, calf raises

Manage Sets, Reps, and Rest Periods

For hypertrophy, the goal is to accumulate sufficient training volume. Aim for 8-12+ total sets per muscle group per week. Rep ranges can vary, but most of your work should be within the 6-15 rep range (4).

  • Compound Lifts: 3-4 sets of 6-10 reps.
  • Isolation Lifts: 2-3 sets of 10-15 reps.

Rest periods are also important. For hypertrophy, rest 1.5-3 minutes between sets. This allows for adequate recovery so you can maintain performance on subsequent sets without allowing your heart rate to drop completely (8).

For those interested in a pre-designed plan, explore this 4-day workout routine for beginners for a solid starting point.

Which Exercises Are Best for Lower- vs Upper-Body Days in This Split?

Exercise selection is key to a well-rounded program (9). A good split includes a mix of compound and isolation exercises that target muscles from different angles.

For upper body days, focus on a balance between pushing and pulling movements.

  • Horizontal Push: barbell bench press, dumbbell bench press
  • Horizontal Pull: barbell rows, T-bar rows
  • Vertical Push: overhead press, Arnold press
  • Vertical Pull: pull-ups, lat pulldowns
  • Isolation: bicep curls, tricep pushdowns, lateral raises

For lower-body days, ensure you’re training both the quads and the posterior chain (hamstrings and glutes).

  • Quad-Dominant: back squats, leg press, leg extensions
  • Hamstring/Glute-Dominant: Romanian deadlifts, good mornings, leg curls
  • Glute-Focused: hip thrusts, glute bridges
  • Calves: standing and seated calf raises

Read more: Dumbbell and Bench Workout Plan for Beginners: A Practical Guide

How Should Rest Days Be Scheduled in a 4-Day Upper-Lower Split?

Rest days are when your muscles repair and grow stronger (4). In a 4-day split, you have three rest days. How you use them matters.

You should have total rest days and active rest days. Total rest means doing minimal physical activity to allow your body to fully recover. However, active rest involves low-intensity activities that promote blood flow and reduce muscle soreness without adding significant training stress (10).

A great schedule is the 2-on, 1-off, 2-on, 2-off approach:

  • Monday: Upper (training)
  • Tuesday: Lower (training)
  • Wednesday: Active rest
  • Thursday: Upper (training)
  • Friday: Lower (training)
  • Saturday: Active rest
  • Sunday: Total rest

Examples of active recovery include a light walk, a gentle bike ride, yoga, or stretching. These activities are believed to help with lactic acid release, may reduce stiffness, and could support the overall recovery process.

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Can Beginners Use a 4-Day Upper-Lower Split Effectively?

Yes, beginners can use this split effectively. It provides a structured way to learn key exercises and ensures adequate frequency for muscle growth without being overwhelming. The split introduces the concept of dividing training by body part, which is a fundamental programming strategy.

However, beginners should be mindful of several things:

  • Focus on Form: Prioritize learning correct technique over lifting heavy weights.
  • Manage Volume: Start with fewer sets (e.g. 2 sets per exercise) and gradually increase as you get stronger.
  • Listen to Your Body: If you feel excessive fatigue or soreness, it may be a sign to dial it back. Novice lifters should have 1-3 days of rest between sessions that stress the same muscle groups.

Is a 4-Day Upper-Lower Split Good for Fat Loss?

Yes, a 4-day upper-lower split is excellent for fat loss. Resistance training is essential during a fat loss phase as it helps preserve muscle mass while you’re in a calorie deficit. The more muscle you have, the higher your metabolic rate, which means you burn more calories at rest (11).

This split combines heavy compound lifting with higher-rep isolation work, which is a potent combination for burning calories and stimulating muscle. When combined with a proper diet and some cardiovascular exercise, it’s a highly effective strategy for getting leaner while maintaining your strength.

If your primary goal is to get lean, you can find tailored programs in this guide on a 4-day workout routine to get ripped. If you want to build muscle without excess fat, our 4-day workout routine for lean muscle provides a detailed path to your goal.

Frequently Asked Questions

  • Who benefits most from a 4-day upper-lower split?

Intermediate lifters – those with 6 months to 2 years of consistent training experience – often benefit the most. They have a solid foundation of strength and technique and are ready to increase their training frequency and volume to continue making progress. However, beginners and advanced lifters can also adapt the split to suit their needs.

  • Can a 4-day upper-lower split work with only dumbbells?

Absolutely. Dumbbells are incredibly versatile and can be used for nearly every major exercise. You can perform dumbbell bench presses, goblet squats, Romanian deadlifts, and rows. A dumbbell-only upper-lower split is a fantastic option for those with limited equipment or who train at home.

  • How can you balance volume between upper and lower days?

Aim for a similar number of total sets on upper- and lower-body days to ensure balanced development. A good starting point is 12-16 total sets per workout. 

For example, on an upper day, you might do 6-8 sets for your chest and back, plus 3-4 sets each for shoulders, biceps, and triceps. On a lower day, you could do 6-8 sets for quads and hamstrings, plus 3-4 sets for glutes and calves.

  • What's the best warm-up for upper-lower split workouts?

A good warm-up prepares your body for the workout ahead, reducing injury risk and improving performance (12). Start with 5-10 minutes of light cardio to increase your heart rate, then perform dynamic stretches and mobility drills specific to the body parts you’re training.

  • Upper-Body Day: arm circles, thoracic spine rotations, band pull-aparts.
  • Lower-Body Day: leg swings, hip circles, bodyweight squats.
    Finally, perform a few light warm-up sets of your first exercise before moving to your working weight.

The Bottom Line

The 4-day upper-lower split is a time-tested, science-backed approach to building muscle and strength. It offers the perfect balance of training frequency, volume, and recovery, which makes it suitable for a wide range of lifters. By structuring your workouts with a mix of compound and isolation exercises and prioritizing rest, you’ll be on the fast track to achieving your hypertrophy goals.

DISCLAIMER:

This article is intended for general informational purposes only and does not serve to address individual circumstances. It is not a substitute for professional advice or help and should not be relied on for making any kind of decision-making. Any action taken as a direct or indirect result of the information in this article is entirely at your own risk and is your sole responsibility.

BetterMe, its content staff, and its medical advisors accept no responsibility for inaccuracies, errors, misstatements, inconsistencies, or omissions and specifically disclaim any liability, loss or risk, personal, professional or otherwise, which may be incurred as a consequence, directly or indirectly, of the use and/or application of any content.

You should always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or your specific situation. Never disregard professional medical advice or delay seeking it because of BetterMe content. If you suspect or think you may have a medical emergency, call your doctor.

SOURCES:

  1. Effects of Resistance Training Frequency on Measures of Muscle Hypertrophy: A Systematic Review and Meta-Analysis (2016, link.springer.com)
  2. Resistance training‐induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after attenuation of muscle damage (2016, pmc.ncbi.nlm.nih.gov)
  3. The Effect of Chronic Exercise on Energy and Fatigue States: A Systematic Review and Meta-Analysis of Randomized Trials (2022, frontiersin.org)
  4. The Importance of Recovery in Resistance Training Microcycle Construction (2024, pmc.ncbi.nlm.nih.gov)
  5. A Systematic Review of the Effects of Different Resistance Training Volumes on Muscle Hypertrophy (2022, jhk.termedia.pl)
  6. 5 Benefits of Compound Exercises (2016, acefitness.org)
  7. Hypertrophic Effects of Single- Versus Multi-Joint Exercise of the Limb Muscles: A Systematic Review and Meta-analysis (2023, journals.lww.com)
  8. Profiling Rest Intervals between Sets and Associated Factors in Resistance Training Participants (2018, mdpi.com)
  9. Resistance training exercise selection: efficiency, safety and comfort analysis method (2021, scielo.br)
  10. A Systematic Review on the Effectiveness of Active Recovery Interventions on Athletic Performance of Professional-, Collegiate-, and Competitive-Level Adult Athletes (2019, journals.lww.com)
  11. Increasing muscle mass to improve metabolism (2013, pmc.ncbi.nlm.nih.gov)
  12. Revisiting the ‘Whys’ and ‘Hows’ of the Warm-Up: Are We Asking the Right Questions? (2024, link.springer.com)
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