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5-Day Workout Plan for Muscle Gain: The Ultimate Guide

A 5-day workout split is often dismissed as “too much” or a one-way ticket to overtraining. However, here’s what research has actually shown: when programmed correctly using evidence-based principles, a 5-day split can be one of the most effective approaches for muscle gain. The key lies in understanding how to structure your training volume, exercise selection, and recovery to maximize hypertrophy while minimizing injury risk.

This guide will walk you through everything you need to know about creating and implementing a 5-day workout plan that delivers real results.

We’ll explore the science behind training frequency, optimal exercise selection, and how to structure your sessions for balanced muscle growth. By the end, you’ll have a complete understanding of how to make a 5-day split work for your muscle-building goals.

Can You Build Muscle with 5 Workouts per Week?

The relationship between training frequency and muscle hypertrophy has been extensively studied. Research has shown that muscle protein synthesis (MPS) remains elevated for approximately 24-48 hours after resistance training (1). This means that training a muscle group twice per week can provide superior muscle-building stimulus compared to once-weekly training.

A 5-day workout split allows you to hit each major muscle group twice within a seven-day period. This frequency aligns perfectly with the body’s recovery and adaptation cycles. When you train your chest on Monday and Thursday, for example, you’re providing stimulus just as the previous session’s effects are diminishing.

Training volume plays a crucial role in this equation. The National Strength and Conditioning Association (NSCA) guidelines suggest that moderate to high training volumes produce greater hypertrophic responses than low volumes (2). A 5-day split allows you to distribute this volume across multiple sessions, which prevents excessive fatigue while maintaining high stimulus.

The key is understanding that more isn’t always better. A well-designed 5-day program respects the principle of specificity and progressive overload. Each session should have a clear purpose, whether it’s emphasizing compound movements, targeting specific muscle groups, or focusing on different rep ranges.

Recovery becomes paramount with higher training frequencies. General Adaptation Syndrome (GAS) tells us that our bodies move through alarm, resistance, and exhaustion phases (3). A properly structured 5-day split keeps you in the resistance phase, where positive adaptations occur, without pushing into exhaustion.

Which Exercises Deliver the Fastest Results in a 5-Day Muscle Gain Plan?

Exercise selection forms the foundation of any successful muscle-building program. The NSCA emphasizes that compound movements should form the backbone of your training, with isolation exercises serving as accessories to target specific weaknesses or imbalances (2).

Multi-joint exercises such as squats, deadlifts, bench press, and pull-ups activate multiple muscle groups simultaneously. This creates a greater overall stimulus for muscle growth and allows you to handle heavier loads (4). These movements also improve intermuscular coordination, which is essential for long-term strength development (5).

The squat stands out as arguably the most important exercise in your arsenal. It targets the quadriceps, glutes, hamstrings, and core while requiring significant stabilization from your entire body (6). Similarly, the deadlift engages your posterior chain, core, and grip strength in one powerful movement (7).

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For upper-body development, the bench press and its variations remain gold standards for chest, shoulder, and tricep development (8). Pull-ups and their variations balance this by strengthening your back, biceps, and rear deltoids. These exercises create the foundation for aesthetic and functional upper body strength (9).

Progressive overload remains the driving force behind muscle growth. The NSCA guidelines suggest that resistance should be increased when you can perform more repetitions than the prescribed range (10). This may mean adding weight, increasing reps, or improving time under tension.

Isolation exercises serve specific purposes within a 5-day split. Bicep curls, tricep extensions, and lateral raises allow you to target muscles that might be underdeveloped or need additional volume. These exercises also provide variety and can help prevent overuse injuries from repetitive compound movements (11).

Read more: Which Gym Workout Split Should You Use?

Which Muscle Groups Should You Pair in a 5-Day Workout Plan?

Muscle pairing strategies can make or break your 5-day split. The most effective approach considers both anatomical relationships and recovery patterns. Muscles that work together in compound movements should generally be trained together, while antagonistic muscle groups can be paired for balanced development (12).

The push-pull concept provides excellent guidance for pairing decisions. Push muscles (chest, shoulders, triceps) work together during pressing movements, while pull muscles (back, biceps) collaborate during rowing and pulling exercises. This natural synergy allows you to train related muscle groups when they’re fresh and ready to work together.

Lower-body muscles present unique pairing challenges due to their size and the systemic fatigue they create. The quadriceps, hamstrings, and glutes all play roles in fundamental movement patterns like squatting and deadlifting. Training them together allows for more efficient movement patterns and better overall development.

Upper-body and lower-body splits offer another effective pairing strategy. This approach allows for more recovery time between sessions targeting the same muscle groups (13). Your legs can recover while you train your upper body, and vice versa. This becomes particularly valuable as training intensity increases.

Antagonistic muscle pairings can enhance both efficiency and recovery (14). For example, training biceps after back work allows the biceps to recover while you perform back exercises. This approach can also improve blood flow and reduce overall session time.

The role of the nervous system in muscle pairing cannot be ignored. Large compound movements create significant neural fatigue, which affects your ability to perform subsequent exercises (15). Pairing exercises that complement rather than compete for neural resources leads to better overall performance.

How To Structure a 5-Day Workout Plan for Balanced Muscle Growth?

A push-pull-legs split with an upper-lower component creates the most balanced approach for a 5-day workout routine. This structure allows you to train each muscle group twice per week while providing adequate recovery time between sessions.

  • Day 1

Day 1 focuses on push movements, emphasizing chest, shoulders, and triceps. This session builds around compound pressing movements like bench press, overhead press, and dips. The unified movement patterns allow these muscle groups to work synergistically, maximizing both strength and muscle development.

  • Day 2

Day 2 shifts to pull movements, targeting back, biceps, and rear deltoids. Pull-ups, rows, and face pulls form the foundation, with bicep curls and reverse flies providing additional volume. This session balances the previous day’s work and promotes structural balance.

  • Day 3

Day 3 focuses on the legs, including quadriceps, hamstrings, glutes, and calves. Squats and deadlifts anchor this session, with lunges, leg curls, and calf raises providing comprehensive lower-body development. The large muscle groups involved create significant metabolic stress, promoting overall muscle growth.

  • Day 4

Day 4 returns to upper body training but with a different emphasis. This session combines pushing and pulling movements in a more integrated fashion. It may include exercises such as bench press supersetted with rows, or overhead press paired with pull-ups. This approach provides additional volume while preventing overuse injuries.

  • Day 5

Day 5 completes the cycle with another lower-body session, but with different exercise selections and intensities. This might emphasize single-leg work, plyometric exercises, or different rep ranges. The variety prevents accommodation while ensuring complete lower-body development.

  • Rest Dats

Rest days are an essential component of this structure. Active recovery activities such as walking, light stretching, or mobility work can enhance recovery without impeding adaptation. Complete rest days allow your nervous system to recover fully. Uncover the surprising benefits of the active rest day in our past article.

What Is a Pump-Inducing 5-Day Workout Plan for Muscle Gain?

Here’s a comprehensive 5-day workout plan based on the push-pull-legs-upper-lower structure:

Day 1: Push (Chest, Shoulders, Triceps)

  • Barbell bench press: 4 sets of 6-8 reps
  • Chest fly: 3 sets of 8-10 reps
  • Incline dumbbell press: 3 sets of 10-12 reps
  • Lateral raises to front raise superset: 3 sets of 12-15 reps
  • Tricep dips: 3 sets of 10-12 reps
  • Tricep pushdowns: 3 sets of 12-15 reps

Day 2: Pull (Back, Biceps, Rear Delts)

  • Pull-ups: 4 sets of 6-10 reps
  • Bent-over barbell row: 4 sets of 8-10 reps
  • Lat pulldown: 3 sets of 10-12 reps
  • Face pulls: 3 sets of 12-15 reps
  • Barbell curls: 3 sets of 10-12 reps
  • Hammer curls: 3 sets of 12-15 reps

Day 3: Legs (Quads, Hamstrings, Glutes, Calves)

  • Back squat: 4 sets of 6-8 reps
  • Romanian deadlift: 4 sets of 8-10 reps
  • Bulgarian split squats: 3 sets of 10-12 reps each leg
  • Leg curls: 3 sets of 12-15 reps
  • Calf raises: 4 sets of 15-20 reps

Day 4: Upper Body (Combined Push/Pull)

  • Incline barbell press: 4 sets of 8-10 reps
  • Seated cable row: 4 sets of 8-10 reps
  • Dumbbell shoulder press: 3 sets of 10-12 reps
  • Chin-ups: 3 sets of 8-12 reps
  • Close-grip bench press: 3 sets of 10-12 reps
  • Preacher curls: 3 sets of 12-15 reps

Day 5: Lower Body (Different Emphasis)

  • Front squat: 4 sets of 8-10 reps
  • Stiff-leg deadlift: 4 sets of 10-12 reps
  • Leg press: 3 sets of 15-20 reps
  • Walking lunges: 3 sets of 12 steps each leg
  • Seated calf raises: 4 sets of 15-20 reps

This program emphasizes progressive overload through various rep ranges. Lower rep ranges (6-8) focus on strength development, moderate ranges (8-12) target hypertrophy, and higher ranges (12-20) promote muscular endurance and metabolic stress.

Read more: Lean Calisthenics Body Weight Workout for Beginners

How Much Rest Between Sets Maximizes 5-Day Plan Results?

Rest period optimization has evolved significantly based on recent research. The traditional approach of short rest periods for hypertrophy has been challenged by studies that have shown that longer rest periods may actually enhance muscle growth by allowing for better performance in subsequent sets (16).

For compound movements such as squats, deadlifts, and bench press, rest periods of 3-5 minutes allow for adequate phosphocreatine replenishment (17). This energy system provides the power for high-intensity efforts. Insufficient rest compromises load and volume, both of which are essential for muscle growth.

Isolation exercises can utilize slightly shorter rest periods of 1-2 minutes (17). These exercises place less demand on the energy systems and nervous system (11). However, the focus should remain on maintaining performance rather than rushing through sets.

The relationship between rest periods and training volume becomes particularly important in a 5-day split. Longer rest periods allow you to maintain higher loads across all sets, leading to greater total volume. This volume accumulation drives muscle growth more effectively than fatigued sets with reduced loads (18).

Individual factors influence optimal rest periods. Training experience, current fitness level, and specific goals all play a role. More experienced trainees may require longer rest periods due to their ability to generate greater force and create more fatigue.

Heart rate recovery can serve as a practical guide for monitoring fatigue and rest periods (19). When your heart rate returns to approximately 60-70% of its peak exercise level, you’re physiologically ready for the next set. This approach individualizes rest periods based on your current recovery capacity.

What Are Some Post-Workout Meals to Maximize the Effect of a Workout?

Post-workout nutrition plays a supporting role in muscle growth, although its importance has been somewhat overstated in popular fitness culture. The concept of an “anabolic window” requiring immediate protein consumption has been largely debunked by recent research (20).

Protein intake remains crucial for muscle protein synthesis, but the timing is less critical than total daily intake. Research suggests consuming 20-40 grams of high-quality protein within 2-3 hours post-workout can optimize recovery and adaptation. This provides the amino acids that are necessary for muscle repair and growth (21).

Carbohydrate intake becomes important primarily for glycogen replenishment, particularly if you’re training again within 24 hours (22). For most people who are following a 5-day split, normal dietary carbohydrate intake is sufficient for recovery. However, adding 30-60 grams of carbohydrates during exercise can enhance recovery and subsequent performance (23).

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Here are some practical post-workout meal options:

Option 1: Protein and Carb Combo

  • Grilled chicken breast with sweet potato and vegetables
  • Provides complete amino acid profile and complex carbohydrates

Option 2: Convenient Recovery Shake

  • Whey protein powder with banana and milk
  • Quick absorption and convenient preparation

Option 3: Whole Food Approach

  • Greek yogurt with berries and granola
  • Combines protein, carbohydrates, and micronutrients

Option 4: Balanced Meal

  • Salmon with quinoa and roasted vegetables
  • Provides protein, healthy fats, and complex carbohydrates

The key is consistency with your overall nutrition plan rather than perfect post-workout timing. Focus on meeting your daily protein requirements (1.4-2.0 grams per pound of body weight) and maintaining adequate energy intake to support training and recovery (24).

Hydration deserves equal attention to solid nutrition. Replacing fluids lost during training supports all physiological processes involved in recovery and adaptation. Your water intake should be individualized based on sweat rate and training duration.

Frequently Asked Questions

  • Should you train your abs every day?

Training your abs every day isn’t recommended. As with all muscles, your abdominal muscles need time to recover and rebuild after being worked. Overtraining can hinder muscle growth and increase the risk of injury. Instead, focus on training abs 2-3 times per week using a mix of exercises that target different areas of your core. Also remember that the core is involved in every lift that you are doing in the gym. Even if you’re not directly working your core, it’s still receiving stimulus when strength training.

  • Which muscles shouldn’t be trained together?

Muscles that are heavily involved in supporting one another during exercises should ideally not be trained together on the same day. For example, training the chest and shoulders together can lead to overuse, as they both engage in pushing movements. 

Similarly, biceps and back may be too taxing to train simultaneously as the biceps are already activated during most pulling exercises. It’s best to pair muscles with complementary or alternating functions, such as back and triceps or chest and biceps.

  • Can I do planks every day?

Yes, you can do planks daily, as they don’t strain your muscles in the same way weighted exercises do. However, you must ensure proper form to avoid putting stress on your lower back and wrists. Planks primarily enhance core endurance and stability, so combining them with a variety of core exercises offers a more balanced approach to building strength.

  • Can I train my biceps every day?

Training your biceps daily is not advisable. As with any muscle group, the biceps need time to recover and grow after workouts. Overtraining them without enough rest can lead to stagnation in progress and increase the chance of tendon overuse or injury (25). Instead, aim to train your biceps 1-3 times per week, depending on your fitness level and overall workout plan.

The Bottom Line

A well-structured 5-day workout plan can be incredibly effective for muscle gain when designed with proper exercise selection, intelligent muscle pairing, and adequate recovery protocols. The key lies in understanding that more training isn’t automatically better – it’s about optimizing the relationship between stimulus and recovery.

The push-pull-legs-upper-lower structure provides a balanced approach that allows for high training frequency while preventing overuse injuries. Each muscle group receives attention twice per week, which aligns with the body’s natural recovery cycles and muscle protein synthesis patterns.

Start with this foundation, track your progress, and adjust based on your individual response. The combination of scientific principles and consistent application will help you achieve the muscle-building results you’re looking for.

DISCLAIMER:

This article is intended for general informational purposes only and does not serve to address individual circumstances. It is not a substitute for professional advice or help and should not be relied on for making any kind of decision-making. Any action taken as a direct or indirect result of the information in this article is entirely at your own risk and is your sole responsibility.

BetterMe, its content staff, and its medical advisors accept no responsibility for inaccuracies, errors, misstatements, inconsistencies, or omissions and specifically disclaim any liability, loss or risk, personal, professional or otherwise, which may be incurred as a consequence, directly or indirectly, of the use and/or application of any content.

You should always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or your specific situation. Never disregard professional medical advice or delay seeking it because of BetterMe content. If you suspect or think you may have a medical emergency, call your doctor.

SOURCES:

  1. Nutritional regulation of muscle protein synthesis with resistance exercise: strategies to enhance anabolism (2012, biomedcentral.com)
  2. FOUNDATIONS OF FITNESS PROGRAMMING (2015, nsca.com)
  3. Evaluating the Role of Hans Selye in the Modern History of Stress – Stress, Shock, and Adaptation in the Twentieth Century (2014, ncbi.nlm.nih.gov)
  4. Progression Models in Resistance Training for Healthy Adults (2009, journals.lww.com)
  5. Morphological and Neurological Contributions to Increased Strength (2007, link.springer.com)
  6. A Biomechanical Review of the Squat Exercise: Implications for Clinical Practice (2024, pmc.ncbi.nlm.nih.gov)
  7. UNDERSTANDING THE DEADLIFT AND ITS VARIATIONS (2020, journals.lww.com)
  8. The Effects of Bench Press Variations in Competitive Athletes on Muscle Activity and Performance (2017, pmc.ncbi.nlm.nih.gov)
  9. A Comparison of Muscle Activation during the Pull-up and Three Alternative Pulling Exercises (2018, researchgate.net)
  10. BASICS OF STRENGTH AND CONDITIONING MANUAL (2010, nsca.com)
  11. Do Single-Joint Exercises Enhance Functional Fitness? (2012, journals.lww.com)
  12. Agonist-Antagonist Paired Set Resistance Training: A Brief Review (2010, journals.lww.com)
  13. Upper/Lower Splits Explained: Getting Workout Splits Right (n.d., blog.nasm.org)
  14. Antagonistic co-contraction can minimize muscular effort in systems with uncertainty (2022, pmc.ncbi.nlm.nih.gov)
  15. Neural Contributions to Muscle Fatigue: From the Brain to the Muscle and Back Again (2016, pmc.ncbi.nlm.nih.gov)
  16. Longer Interset Rest Periods Enhance Muscle Strength and Hypertrophy in Resistance-Trained Men (2016, journals.lww.com)
  17. No Time to Lift? Designing Time-Efficient Training Programs for Strength and Hypertrophy: A Narrative Review (2021, pmc.ncbi.nlm.nih.gov)
  18. Rest interval between sets in strength training (2009, pubmed.ncbi.nlm.nih.gov)
  19. A Systematic Review on Heart-Rate Recovery to Monitor Changes in Training Status in Athletes (2012, researchgate.net)
  20. The effect of protein timing on muscle strength and hypertrophy: a meta-analysis (2013, pmc.ncbi.nlm.nih.gov)
  21. Nutritional Strategies to Improve Post-exercise Recovery and Subsequent Exercise Performance: A Narrative Review (2025, link.springer.com)
  22. Fundamentals of glycogen metabolism for coaches and athletes (2018, pmc.ncbi.nlm.nih.gov)
  23. Nutrition and Athletic Performance (2009, journals.lww.com)
  24. International Society of Sports Nutrition Position Stand: protein and exercise (2017, jissn.biomedcentral.com)
  25. Overtraining Syndrome as a Complex Systems Phenomenon (2022, frontiersin.org)
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